The Science Behind VantaLab

At VantaLab, our formulations are built on the principle of reversing cellular dysfunction at the molecular level. Aging skin is not merely a surface-level concern—it is a reflection of deeper biological processes driven by inflammation, environmental damage, and most crucially, cellular senescence.

What Happens to Aging Skin?

As we age, our skin undergoes a cascade of biological changes:

• Collagen Breakdown: The extracellular matrix loses structural integrity, resulting in wrinkles and sagging.
• Barrier Dysfunction: A decline in lipid and protein levels weakens the skin’s defense and hydration capacity.
• Cellular Senescence: Cells stop dividing but remain metabolically active, releasing inflammatory molecules that damage surrounding tissue.
• Decreased Turnover: Skin renewal slows, leading to buildup, dullness, and impaired healing.

Microscopy reveals senescent fibroblasts—enlarged, vacuolated, and metabolically toxic to their surroundings.

Diagram showing nuclear envelope damage, chromatin reorganization, SASP signaling, and metabolic drift—all hallmarks of cellular senescence.

How We Target These Pathways

• Niacinamide: Strengthens the epidermal barrier and improves ceramide production.
• Acetyl Hexapeptide-8: Relaxes muscle contractions to reduce dynamic wrinkles.
• EGCG (Green Tea Extract): Neutralizes oxidative stress and modulates inflammation.
• Bakuchiol: A retinol alternative that stimulates collagen without irritation.
• Copper Tripeptide-1: Repairs tissue and enhances skin elasticity.
• Sodium DNA (PDRN): Promotes healing and fibroblast regeneration.
• Snow Mushroom Extract: A natural humectant with superior hydration retention.

Why AI Personalization?

Our AI engine is trained on clinical data and dermatology literature to match formulations to your unique skin state. It allows us to:

• Identify ingredient synergies
• Avoid interactions and sensitivities
• Continuously adapt to your skin's changes

Our motto: Precision anti-aging — coded to your biology.

Works Cited

1. Campisi, J. (2013). Aging, cellular senescence, and cancer. Annual Review of Physiology, 75, 685–705.
2. Ziegler DV, Wiley CD. Cellular senescence in the skin: mechanisms and clinical applications. Clin Cosmet Investig Dermatol. 2020;13:1231–1241.
3. Kaur S et al. Topical niacinamide in dermatology. Dermatol Ther. 2018;31(6):e12644.
4. Varani J et al. Decreased collagen production in chronologically aged skin. Am J Pathol. 2006;168(6):1861–1868.
5. Choi JH et al. Anti-aging potential of bakuchiol. Int J Mol Sci. 2021;22(23):12564.
6. Tong T et al. Epigallocatechin gallate prevents senescence via AMPK pathway. J Gerontol A Biol Sci Med Sci. 2019;74(5):e59–e65.
7. Pickart L. The human tripeptide GHK and tissue remodeling. J Biomater Sci Polym Ed. 2008;19(8):969–988.
8. Zarei M et al. Polydeoxyribonucleotide (PDRN) in dermatology. Skin Pharmacol Physiol. 2020;33(1):1–10.